Action Potential
Drugs act at various sites
- Neurotransmitter Synthesis
- Neurotransmitter Storage
- Neurotransmitter Release
- Catabolism of Neurotransmitter
- Re uptake of Neurotransmitter
- Receptors
- Ion Channels
Neurotransmitters
- Monoamines : Dopamine, NA, Seratonin (5HT)
- Acetylcholine
- GABA
- Glycine
- Glutamine
- Peptides :Opioids, Substance P, CGRP
Neurotransmitter Receptors
- Inotrophic Receptors
- Exitatory Post Synaptic Potentials (Depolarization)
- Inhibitory Post Synaptic Potentials (Hyperpolarization)
- Metabotropic Receptors
- Slow onset of effects
- Second messenger systems
- G protein coupled receptors
- Diverse effects
- Ion channel opening
- Protein modification
Neuronal Dysfunction
- Due to Lack of NT
- Parkinson's - Dopamine
- Depression - Monoamines
- Alzhimeirs - Ach
- Due to Excess of NT
- Other
- Migraine - Neurogenic Inflamation
- Epilepsy - Excessive Depolarization
- CNS Drugs should be able to cross the blood brain barrier.SO to do that either they should be lipid soluble or they need to have transporters
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